An Intermediate Along the Recovery Stroke of Myosin VI Revealed by X-Ray Crystallography and Molecular Dynamics
Published in Proceedings of the National Academy of Sciences, 2018
Florian E. C. Blanc, Tatiana Isabet, Hannah Benisty, H. Lee Sweeney, Marco Cecchini, Anne Houdusse
Proceedings of the National Academy of Sciences, 2018
With crystallography, conventional MD and ABF, we characterise a structural state of the myosin motor domain that suggests a “ratchet-like” mechanism in which lever-arm repriming precedes active site closure and is not strongly coupled to it.