An Intermediate Along the Recovery Stroke of Myosin VI Revealed by X-ray Crystallography and Molecular Dynamics
Published in Proceedings of the National Academy of Sciences, 2018
Recommended citation: Florian Blanc, Tatiana Isabet, Hannah Benisty, H. Lee Sweeney, Marco Cecchini, Anne Houdusse (2018). "An Intermediate Along the Recovery Stroke of Myosin VI Revealed by X-ray Crystallography and Molecular Dynamics." Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1711512115
With crystallography, conventional MD and ABF, we characterise a structural state of the myosin motor domain which suggests a “ratchet-like” mechanism in which lever-arm repriming precedes active site closure and is not strongly coupled to it.