I am a CNRS Research Scientist in the Biophysics of Complex Systems team at Institut des Sciences Analytiques, France.
My research falls under computational molecular biophysics, physical chemistry, and integrative structural biology.
I strive to understand how biomolecular function emerges from structural dynamics by describing the atomically-detailed mechanisms involved. For this, I combine molecular dynamics simulations, machine learning, and experimental biophysics.
I investigate complex molecular mechanisms in systems ranging from short peptides to large molecular motors (myosin, ATP synthase), with the occasional venture into supra-molecular chemistry. I also contributed to characterizing the conformational dynamics and immunogenic sites of the SARS-CoV-2 spike protein in the early days of the Covid-19 pandemic. More recently, I started to explore how to apply deep learning methods to the analysis of biophysical experiments.
I am always looking for motivated students to work with, so check out the open positions or contact me directly at florian.blanc [at] cnrs [dot] com.
News
- May 4, 2026 — We have an open position for a Master’s thesis. Starting date flexible between September 2026 and March 2027.
- April 27, 2026 — Student-engineers Louison Grizard and Axel Lukaszewicz from CPE Lyon are joining us for a short project on silver-binding peptides.
- March 24–26, 2026 — Invited talk at CECAM Workshop on Cryo-EM in Toulouse.
- February 10, 2026 — New paper published in J. Phys. Chem. Lett.
- February 9, 2026 — Raphael Desrues is starting his Master’s thesis on peptide oligomerization, supervised jointly by myself and Fabien Chirot from Institut Lumière et Matière.