Mechanism of Proton-Powered c-Ring Rotation in a Mitochondrial ATP Synthase
Published in Proceedings of the National Academy of Sciences, 2024
Recommended citation: Blanc, Florian E. C. and Hummer, Gerhard (2024). "Mechanism of Proton-Powered c-Ring Rotation in a Mitochondrial ATP Synthase." Proceedings of the National Academy of Sciences. 12111. https://doi.org/10.1073/pnas.2314199121
With extensive eABF calculations, we reveal the mechanism of the 36 deg rotation step of the ATP synthase rotor, clarifying the water-mediated proton transfer pathway and the role of experimentally-detected intermediates.