Antibody Accessibility Determines Location of Spike Surface Mutations in SARS-CoV-2 Variants
Published in PLOS Computational Biology, 2023
Recommended citation: von Bülow, S., Sikora, M., Blanc, F.E.C., Covino, R., Hummer, G. (2023). "Antibody Accessibility Determines Location of Spike Surface Mutations in SARS-CoV-2 Variants." PLOS Computational Biology. 191. https://doi.org/10.1371/journal.pcbi.1010822
Using data from the early days of the pandemic, we show that surface accessibility to antibodies -estimated using a simple computational protocol- is a predictor of mutation sites found in later variants of concern.